Long-term p110a PI3K inactivation exerts a beneficial effect on metabolism
نویسندگان
چکیده
(1) Institute of Healthy Ageing and Department of Ge Environment, University College London, Darwin Bu London, UK (2) Centre for Cell Signalling, Barts Cancer Institute, Qu of London, Charterhouse Square, London, UK (3) Promed Laboratoire Médical, Marly, Switzerland (4) Metabolic Signalling Group, Medical Research Cou Centre, Imperial College, Du Cane Road, London, UK *Corresponding author: Tel: þ44 20 3108 1612; Fax: E-mail: [email protected] **Corresponding author: Tel: þ44 207 878 4066; Fax: E-mail: [email protected]
منابع مشابه
Long-term p110α PI3K inactivation exerts a beneficial effect on metabolism
The insulin/insulin-like growth factor-1 signalling (IIS) pathway regulates cellular and organismal metabolism and controls the rate of aging. Gain-of-function mutations in p110α, the principal mammalian IIS-responsive isoform of PI 3-kinase (PI3K), promote cancer. In contrast, loss-of-function mutations in p110α impair insulin signalling and cause insulin resistance, inducing a pre-diabetic st...
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